A national survey of valganciclovir dosing strategies in pediatric organ transplant recipients
نویسندگان
چکیده
منابع مشابه
New algorithm for valganciclovir dosing in pediatric solid organ transplant recipients
CMV infections are common after SOT. v-GCV is increasingly used in children. The aim of this study was to evaluate presently used dosing algorithms. Data from 104 pediatric SOT recipients (kidney, liver, and heart) aged 0.3-16.9 yr and receiving v-GCV once a day were used for model development and validation with the Pmetrics package for R. Monte Carlo simulations were performed to compare the ...
متن کاملInfections in Pediatric Solid Organ Transplant Recipients.
Infectious complications are an important cause of morbidity and mortality in children undergoing solid organ transplantation. Knowledge gained over the last 30 years provides a growing understanding of these infections. This review identifies risk factors for and timing of infections describes the common infectious syndromes and pathogens seen in children undergoing solid organ transplantation...
متن کاملValganciclovir: Dosing Strategies for Effective Cytomegalovirus Prevention
Valganciclovir has widely become the agent of choice for the prevention of cytomegalovirus in recipients of organ transplants. Optimal dosing is needed to achieve efficacy and avoid toxicity. For subjects at high risk of cytomegalovirus, it is strongly suggested that full-dose (based on renal function) valganciclovir be used. While low-dose valganciclovir appears to be efficacious in some repor...
متن کاملPharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients.
BACKGROUND A randomized, double-blind study was conducted to evaluate the pharmacokinetics of ganciclovir following oral administration of ganciclovir or valganciclovir for prophylaxis of cytomegalovirus (CMV) disease in solid organ transplant recipients (n = 240/372). METHODS The correlations between individual exposure to ganciclovir during prophylaxis, with CMV viremia incidence during and...
متن کاملPopulation pharmacokinetics of ganciclovir in solid-organ transplant recipients receiving oral valganciclovir.
Valganciclovir (VGC) is an oral prodrug of ganciclovir (GCV) recently introduced for prophylaxis and treatment of cytomegalovirus infection. Optimal concentration exposure for effective and safe VGC therapy would require either reproducible VGC absorption and GCV disposition or dosage adjustment based on therapeutic drug monitoring (TDM). We examined GCV population pharmacokinetics in solid org...
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ژورنال
عنوان ژورنال: Clinical Transplantation
سال: 2018
ISSN: 0902-0063
DOI: 10.1111/ctr.13369